Bones before they break.
An evidence series on bone health and fracture prevention, for healthcare professionals. Each article has a bottom line, graded evidence and linked references. The articles are not medical advice for individual patients.
Bone health in perimenopause: evidence for clinicians
Bone loss is fastest from a year before to two years after the last period. Evidence on screening, calcium, vitamin D, exercise and HRT for Indian women.
Read the article →Reviewed 18 October 2026Fracture risk in perimenopause: how to reduce it
Fracture risk around menopause in absolute numbers: what raises it, and how much lifestyle, HRT, bisphosphonates and denosumab lower it. Graded evidence.
Read the article →Reviewed 18 October 2026HRT and bone: who, when and why (clinician guide)
HRT protects bone and treats hot flushes. Graded evidence on fracture benefit, breast cancer, stroke and clot risks, timing, route and guideline positions.
Read the article →Reviewed 18 October 2026Osteoporosis around menopause: 16 evidence answers
16 clinician questions on osteoporosis around menopause: DXA, FRAX in India, calcium, vitamin D, HRT, drug choice and stopping, with evidence grades given.
Read the article →Reviewed 18 October 2026How osteoporosis drugs work: builders and savers
How teriparatide, abaloparatide, romosozumab, bisphosphonates, denosumab and raloxifene act on bone, and why a bone builder must be followed by a saver.
Read the article →Reviewed 18 October 2026Sequential vs combination osteoporosis therapy
Anabolic-first then antiresorptive, stopping denosumab safely, switches to avoid and which combinations work: graded evidence from FRAME, ARCH, VERO, DATA.
Read the article →Reviewed 18 October 2026GLP-1 and obesity drugs: effect on bone (evidence)
Do semaglutide, liraglutide, tirzepatide and other obesity drugs harm bone? Graded evidence on BMD, lean mass, fracture risk and ways to protect bone.
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